A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier | Zendy

Grinda Marion | Zendy; Clarhaut Jonathan | Zendy; TranoyOpalinski Isabelle | Zendy; Renoux Brigitte | Zendy; Monvoisin Arnaud | Zendy; Cronier Laurent | Zendy; Papot Sébastien | Zendy

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A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier

Author(s) -

Grinda Marion,

Clarhaut Jonathan,

TranoyOpalinski Isabelle,

Renoux Brigitte,

Monvoisin Arnaud,

Cronier Laurent,

Papot Sébastien

Publication year - 2011

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201100355

Subject(s) - prodrug , action (physics) , computer science , computational biology , cytotoxic t cell , cancer , chemistry , combinatorial chemistry , cancer research , information retrieval , biochemistry , biology , genetics , physics , in vitro , quantum mechanics

Amplified action! We developed the therapeutic first targeting system that includes a chemical amplifier programmed both to release two potent anticancer drugs after a single enzymatic activation step and become cytotoxic itself once the amplification process is completed.

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