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A Heterodimeric Glucuronide Prodrug for Cancer Tritherapy: the Double Role of the Chemical Amplifier
Author(s) -
Grinda Marion,
Clarhaut Jonathan,
TranoyOpalinski Isabelle,
Renoux Brigitte,
Monvoisin Arnaud,
Cronier Laurent,
Papot Sébastien
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100355
Subject(s) - prodrug , action (physics) , computer science , computational biology , cytotoxic t cell , cancer , chemistry , combinatorial chemistry , cancer research , information retrieval , biochemistry , biology , genetics , physics , in vitro , quantum mechanics
Amplified action! We developed the therapeutic first targeting system that includes a chemical amplifier programmed both to release two potent anticancer drugs after a single enzymatic activation step and become cytotoxic itself once the amplification process is completed.