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Structure–Activity Relationships of Neuritogenic Gentiside Derivatives
Author(s) -
Luo Yan,
Sun Kaiyue,
Li Lin,
Gao Lijuan,
Wang Guangfa,
Qu Yuan,
Xiang Lan,
Chen Ling,
Hu Yongzhou,
Qi Jianhua
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100348
Subject(s) - linker , alkyl , ring (chemistry) , benzene , stereochemistry , mapk/erk pathway , chemistry , computational biology , biology , computer science , biochemistry , signal transduction , organic chemistry , operating system
Relationship advice: Studying the structure–activity relationships of gentisides revealed that the length of the alkyl chain, number and position of hydroxy groups on the benzene ring, and the type of linker between the benzene ring and alkyl chain have significant effects on their neuritogenic activities. Tetradecyl 2,3‐dihydroxybenzoate (ABG‐001) was the most promising lead compound, inducing significant neurite outgrowth via activation of the ERK signaling pathway.