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Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug‐like and Drug Fragment‐like Molecules
Author(s) -
Nakagawa Shoko,
Bainbridge Katie A.,
Butcher Ken,
Ellis Dave,
Klute Wolfgang,
Ryckmans Thomas
Publication year - 2012
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100339
Subject(s) - fragment (logic) , drug , drug discovery , combinatorial chemistry , chemistry , coupling (piping) , nanotechnology , stereochemistry , computer science , materials science , pharmacology , programming language , biochemistry , medicine , metallurgy
BBC news: CC bond formation reactions are underused by medicinal chemists for the preparation of libraries of compounds with good drug‐like (“rule‐of‐five”) and drug fragment‐like (“rule‐of‐three”) properties. Herein we demonstrate the versatility of the Barluenga boronic coupling (BBC) for the preparation of small drug‐like and drug fragment‐like compounds in parallel.