PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand | Zendy

Demmer Oliver | Zendy; Gourni Eleni | Zendy; Schumacher Udo | Zendy; Kessler Horst | Zendy; Wester HansJürgen | Zendy

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PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand

Author(s) -

Demmer Oliver,

Gourni Eleni,

Schumacher Udo,

Kessler Horst,

Wester HansJürgen

Publication year - 2011

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201100320

Subject(s) - positron emission tomography , ligand (biochemistry) , in vivo , cxcr4 , pet imaging , preclinical imaging , receptor , cancer , molecular imaging , chemistry , cancer research , biophysics , medicine , nuclear medicine , biochemistry , biology , microbiology and biotechnology , chemokine

CXCR4 Imaging: Based on a high‐affinity CXCR4 ligand, an imaging agent for CXCR4‐positive tumors was developed through structure–activity relationship studies. The best compound was evaluated in vivo and shown to have excellent properties as a positron emission tomography (PET) tracer.

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