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PET Imaging of CXCR4 Receptors in Cancer by a New Optimized Ligand
Author(s) -
Demmer Oliver,
Gourni Eleni,
Schumacher Udo,
Kessler Horst,
Wester HansJürgen
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100320
Subject(s) - positron emission tomography , ligand (biochemistry) , in vivo , cxcr4 , pet imaging , preclinical imaging , receptor , cancer , molecular imaging , chemistry , cancer research , biophysics , medicine , nuclear medicine , biochemistry , biology , microbiology and biotechnology , chemokine
CXCR4 Imaging: Based on a high‐affinity CXCR4 ligand, an imaging agent for CXCR4‐positive tumors was developed through structure–activity relationship studies. The best compound was evaluated in vivo and shown to have excellent properties as a positron emission tomography (PET) tracer.