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Encapsulation of Docetaxel into PEGylated Gold Nanoparticles for Vectorization to Cancer Cells
Author(s) -
François Alison,
Laroche Audrey,
Pinaud Noël,
Salmon Lionel,
Ruiz Jaime,
Robert Jacques,
Astruc Didier
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100311
Subject(s) - docetaxel , colloidal gold , cytotoxicity , nanoparticle , dynamic light scattering , cancer cell , chemistry , in vitro , materials science , pharmacology , nanotechnology , medicine , cancer , biochemistry
Encapsulation of docetaxel and its solubilization in water was carried out in PEGylated gold nanoparticles (AuNPs) as shown by 1 H NMR (600 MHz ) and UV/Vis spectroscopy and dynamic light scattering. Vectorization of PEGylated AuNP‐encapsulated docetaxel was probed in vitro toward human colon carcinoma (HCT15) and human breast cancer (MCF7) cells. AuNPs alone presented no cytotoxicity toward either MCF7 or HCT15 adenocarcinoma cells. AuNP–docetaxel was found to be 2.5‐fold more efficient than docetaxel alone against MCF7 cells, and the IC 50 value of AuNP–docetaxel against HCT15 cells was lower than that of free docetaxel; the increased efficiency brought about by AuNP drug encapsulation was ∼1.5‐fold.