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Discovery of α,β‐ and α,γ‐Diamino Acid Scaffolds for the Inhibition of M1 Family Aminopeptidases
Author(s) -
Gumpena Rajesh,
Kishor Chandan,
Ganji Roopa Jones,
Addlagatta Anthony
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100298
Subject(s) - magenta , cyan , paraphrase , amino acid , peptide , lysine , cocrystal , computational biology , chemistry , computer science , biochemistry , stereochemistry , combinatorial chemistry , biology , molecule , physics , organic chemistry , artificial intelligence , optics , inkwell , hydrogen bond , speech recognition
Flipping out! The X‐ray crystal structure of L ‐α,γ‐diaminobutyric acid (DABA, shown in magenta) in complex with an M1 family aminopeptidase reveals that the γ‐amino group displaces the α‐amino group from its original position (as in the complex with lysine, shown in cyan), which in turn results in a peptide flip at Met 260.