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Derivatives of R ‐Aminocarnitine without Ammonium Moiety as Liver Carnitine Palmitoyltransferase I (L‐CPT I) Inhibitors
Author(s) -
Tassoni Emanuela,
Conti Roberto,
Gallo Grazia,
Vincenti Silvia,
Mastrofrancesco Lucilla,
Brunetti Tiziana,
Cabri Walter,
Giannessi Fabio
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100289
Subject(s) - moiety , carnitine , in vivo , chemistry , carnitine o palmitoyltransferase , ammonium , in vitro , biochemistry , combinatorial chemistry , pharmacology , stereochemistry , medicine , biology , enzyme , organic chemistry , genetics , beta oxidation
Dealing with diabetes: Carnitine palmitoyltransferases (CPT) are promising new targets for the treatment of diabetes. Here, derivatives of R ‐aminocarnitine, with the quaternary ammonium moiety replaced by groups lacking a permanent cationic charge, were designed and evaluated in vitro and in vivo as L‐ CPT I inhibitors.