Derivatives of  R ‐Aminocarnitine without Ammonium Moiety as Liver Carnitine Palmitoyltransferase I (L‐CPT I) Inhibitors | Zendy

Tassoni Emanuela | Zendy; Conti Roberto | Zendy; Gallo Grazia | Zendy; Vincenti Silvia | Zendy; Mastrofrancesco Lucilla | Zendy; Brunetti Tiziana | Zendy; Cabri Walter | Zendy; Giannessi Fabio | Zendy

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Derivatives of R ‐Aminocarnitine without Ammonium Moiety as Liver Carnitine Palmitoyltransferase I (L‐CPT I) Inhibitors

Author(s) -

Tassoni Emanuela,

Conti Roberto,

Gallo Grazia,

Vincenti Silvia,

Mastrofrancesco Lucilla,

Brunetti Tiziana,

Cabri Walter,

Giannessi Fabio

Publication year - 2011

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201100289

Subject(s) - moiety , carnitine , in vivo , chemistry , carnitine o palmitoyltransferase , ammonium , in vitro , biochemistry , combinatorial chemistry , pharmacology , stereochemistry , medicine , biology , enzyme , organic chemistry , genetics , beta oxidation

Dealing with diabetes: Carnitine palmitoyltransferases (CPT) are promising new targets for the treatment of diabetes. Here, derivatives of R ‐aminocarnitine, with the quaternary ammonium moiety replaced by groups lacking a permanent cationic charge, were designed and evaluated in vitro and in vivo as L‐ CPT I inhibitors.

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