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Chemical and Pharmacological Studies on Enantiomerically Pure p ‐Methoxytacripyrines, Promising Multi‐Target‐Directed Ligands for the Treatment of Alzheimer’s Disease
Author(s) -
Bartolini Manuela,
Pistolozzi Marco,
Andrisano Vincenza,
Egea Javier,
López Manuela G.,
Iriepa Isabel,
Moraleda Ignacio,
Gálvez Enrique,
MarcoContelles José,
Samadi Abdelouahid
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100239
Subject(s) - disease , chemistry , pharmacology , computational biology , medicine , biology
The S and R isomers of p ‐methoxytacripyrine, a recently developed multi‐target‐directed agent for the treatment of Alzheimer's disease, were investigated. The S enantiomer has emerged as a new promising drug candidate inhibiting cholinesterase activity, amyloid aggregation and showing significant neuroprotective properties against Aβ 25–35 ‐induced cytotoxicity.