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Angiogenin‐Mediated Photosensitizer–Aptamer Conjugate for Photodynamic Therapy
Author(s) -
Yang Xiaohai,
Huang Jin,
Wang Kemin,
Li Wei,
Cui Liang,
Li Xiaoping
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100226
Subject(s) - photosensitizer , photodynamic therapy , aptamer , conjugate , angiogenin , chemistry , chlorin , conjugated system , biophysics , combinatorial chemistry , photochemistry , cancer research , microbiology and biotechnology , medicine , biology , angiogenesis , mathematical analysis , mathematics , organic chemistry , polymer
A molecular conga line! Chlorin e6, a second‐generation photosensitizer, was conjugated with angiogenin and a DNA aptamer to create a novel drug delivery system for photodynamic therapy (PDT). The results show that the photosensitizer is delivered to and internalized by the target cells with high specificity and excellent efficiency. After irradiation by an appropriate light source, the conjugate showed high efficiency and promise as a PDT agent.