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Light‐Activated Release of Nitric Oxide with Fluorescence Reporting in Living Cells
Author(s) -
Vittorino Elisa,
Sciortino Maria Teresa,
Siracusano Gabriel,
Sortino Salvatore
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100198
Subject(s) - nitric oxide , fluorescence , cytotoxicity , intracellular , biophysics , chemistry , microbiology and biotechnology , biochemistry , in vitro , biology , organic chemistry , optics , physics
Prison break! A nitric oxide (NO) photocage incorporating a masked fluorescent unit within the same molecular skeleton allows the photoregulated release of NO within a cell, leading to cytotoxicity. Concomitant release of a strongly fluorescent co‐product serves as an optical reporter for intracellular NO release.
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