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Design, Synthesis, and Biological Evaluation of Ring‐Opened Bengamide Analogues
Author(s) -
Tai WanYi,
Zhang RunTao,
Ma YiMing,
Gu Min,
Liu Gang,
Li Jia,
Nan FaJun
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100164
Subject(s) - ring (chemistry) , cytotoxicity , chemistry , computer science , combinatorial chemistry , computational biology , stereochemistry , biology , biochemistry , organic chemistry , in vitro
Opening up to new possibilities! Ring‐opening of the caprolactam in bengamides, marine natural products isolated from Jaspidae sponges, gives rise to analogues with simplified structures, improved aqueous solubility and potent cytotoxicity against human breast cancer cells, overcoming some of the factors hindering their development as antitumor agents.