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Dopamine D 2 /D 3 Agonists with Potent Iron Chelation, Antioxidant and Neuroprotective Properties: Potential Implication in Symptomatic and Neuroprotective Treatment of Parkinson’s Disease
Author(s) -
Gogoi Sanjib,
Antonio Tamara,
Rajagopalan Subramanian,
Reith Maarten,
Andersen Julie,
Dutta Aloke K.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100140
Subject(s) - neuroprotection , parkinson's disease , dopamine , antioxidant , pharmacology , chelation , chemistry , medicine , neuroscience , disease , biochemistry , psychology , organic chemistry
Grey matters! D‐390 (shown) is a dopamine D 2 /D 3 receptor agonist that chelates iron and possesses antioxidant activity. This compound exhibited efficacious activity in an animal model of Parkinson's disease, indicating blood–brain barrier penetration. In a mouse MPTP neuroprotection model, D‐390 exhibited significant neuroprotection, indicating its possible therapeutic application in both the symptomatic and neuroprotective treatment of Parkinson's disease.