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Selective Inhibition of iNOS by Benzyl‐ and Dibenzyl Derivatives of N ‐(3‐Aminobenzyl)acetamidine
Author(s) -
Fantacuzzi Marialuigia,
Maccallini Cristina,
Lannutti Fabio,
Patruno Antonia,
Masella Simona,
Pesce Mirko,
Speranza Lorenza,
Ammazzalorso Alessandra,
De Filippis Barbara,
Giampietro Letizia,
Re Nazzareno,
Amoroso Rosa
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201100125
Subject(s) - enos , amine gas treating , chemistry , docking (animal) , stereochemistry , selectivity , nitro , derivative (finance) , pharmacology , combinatorial chemistry , nitric oxide , biochemistry , nitric oxide synthase , organic chemistry , medicine , business , alkyl , nursing , catalysis , finance
Picking your NOS: The effect of amine substitution at the 3‐aminomethyl group of known iNOS inhibitor W1400 with mono‐ or disubstituted benzylic groups was evaluated. The o ‐nitro‐benzyl derivative was identified as a potent inhibitor of iNOS, with good selectivity over eNOS. Docking simulations were performed to predict the binding mode of these derivatives in the iNOS and eNOS active sites.