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Inside Cover: Design, Synthesis, and Biological Evaluation of the First Podophyllotoxin Analogues as Potential Vascular‐Disrupting Agents (ChemMedChem 12/2010)
Author(s) -
Labruère Raphaël,
Gautier Benoît,
Testud Marlène,
Seguin Johanne,
Lenoir Christine,
DesbèneFinck Stéphanie,
Helissey Philippe,
Garbay Christiane,
Chabot Guy G.,
Vidal Michel,
GiorgiRenault Sylviane
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201090055
Subject(s) - podophyllotoxin , cover (algebra) , chemistry , combinatorial chemistry , nanotechnology , stereochemistry , materials science , engineering , mechanical engineering
The inside cover picture shows the disruption of endothelial cell cords by a 4‐azapodophyllotoxin analogue at a subtoxic concentration (green arrow). This effect is rapidly reversible after drug washout (red arrow). This is the first example of a compound of this class acting as a vascular‐disrupting agent. For more information, see the Full Paper by Sylviane Giorgi‐Renault et al. on p. 2016 ff.