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Inside Cover: Inhibition of Eimeria tenella CDK‐Related Kinase 2: From Target Identification to Lead Compounds (ChemMedChem 8/2010)
Author(s) -
Engels Kristin,
Beyer Carsten,
Suárez Fernández Maria L.,
Bender Frank,
Gaßel Michael,
Unden Gottfried,
Marhöfer Richard J.,
Mottram Jeremy C.,
Selzer Paul M.
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201090032
Subject(s) - cyclin dependent kinase , chemistry , kinase , docking (animal) , selectivity , cyclin dependent kinase 2 , cyclin dependent kinase 5 , stereochemistry , biophysics , biochemistry , protein kinase a , biology , gene , cell cycle , medicine , nursing , catalysis
The inside cover picture shows the validated drug target EtCRK2, a cyclin‐dependent kinase of Eimeria tenella homologous to human CDK2 and chicken CDK3. A potential EtCRK2 inhibitor is docked into the active site of the protein. The inset shows the intermolecular H‐bonding network. The inhibitor forms a H‐bond to the selectivity switch residue Glu 88 (green stick representation). The positional analogue Lys 89 of human CDK2 and chicken CDK3 is superimposed in a red, translucent stick representation. For more details, see the Full Paper by P. M. Selzer et al. on p. 1259 ff.