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Cover Picture: Molecular Editing of Kinase‐Targeting Resorcylic Acid Lactones (RAL): Fluoroenone RAL (ChemMedChem 5/2010)
Author(s) -
Jogireddy Rajamalleswaramma,
Barluenga Sofia,
Winssinger Nicolas
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201090015
Subject(s) - natural product , chemistry , cover (algebra) , combinatorial chemistry , kinase , stereochemistry , computational biology , biochemistry , biology , mechanical engineering , engineering
The cover picture shows the molecular editing of kinase‐targeting resorcylic acid lactones. While natural products are the result of a long evolution, the biosynthetic machinery is inherently limited, thus leaving opportunities for further pharmacological optimization by chemical synthesis. In this case, substitution of a hydrogen for a fluoride at the α‐position of the Michael acceptor significantly enhanced the stability of the product. This edited natural product also offered new opportunities in its synthetic accessibility. For more information, see the communication by N. Winssinger et al. on p. 670 ff.