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Inside Cover: Selective Pharmacophore Models of Dopamine D 1 and D 2 Full Agonists Based on Extended Pharmacophore Features (ChemMedChem 2/2010)
Author(s) -
Malo Marcus,
Brive Lars,
Luthman Kristina,
Svensson Peder
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201090001
Subject(s) - pharmacophore , chemistry , protonation , hydrogen bond , stereochemistry , dopamine , apomorphine , crystallography , combinatorial chemistry , molecule , receptor , organic chemistry , agonist , biochemistry , ion , neuroscience , biology
The inside cover picture shows apomorphine docked into the dopamine D2 receptor pharmacophore model. The solid spheres represent excluded volumes (grey), H bond acceptors/donors (cyan), functionalities interacting with the protonated amino group (Asp‐TM3) (red), and projected features of the π‐system normals (orange). The mesh spheres represent a cation feature (blue) and an aromatic centroid feature (orange). For more details, see the Full Paper by P. Svensson, et al. on p. 232 ff.