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Synthesis and Radioprotective Properties of Pulvinic Acid Derivatives
Author(s) -
Le Roux Antoine,
Meunier Stéphane,
Le Gall Thierry,
Denis JeanMarc,
Bischoff Pierre,
Wagner Alain
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000391
Subject(s) - chemistry , antioxidant , thymidine , fluorescence , combinatorial chemistry , cell growth , cell , biochemistry , pharmacology , biology , in vitro , physics , quantum mechanics
A high‐throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton‐like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of their radioprotective efficacy in cell culture. Using a cell‐based fluorescent assay, we show that some of these compounds have a pronounced ability to prevent cell death caused by radiation and to allow the subsequent resumption of proliferation. Thus, PADs may be considered as a novel class of radioprotective agents.