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Chemotherapeutic Evaluation of a Synthetic Tubulysin Analogue–Dendrimer Conjugate in C26 Tumor Bearing Mice
Author(s) -
Floyd William C.,
Datta Gopal K.,
Imamura Shinichi,
KielerFerguson Heidi M.,
Jerger Katherine,
Patterson Andrew W.,
Fox Megan E.,
Szoka Francis C.,
Fréchet Jean M. J.,
Ellman Jonathan A.
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000377
Subject(s) - conjugate , dendrimer , pharmacology , chemistry , drug delivery , biochemistry , medicine , mathematics , organic chemistry , mathematical analysis
Conjugate to ameliorate! Polymeric drug delivery using a synthetic tubulysin analogue in C26 tumor bearing mice is described. A single dose of this conjugate (shown) resulted in a 90 % increase in the average lifespan of the mice as compared to groups given a phosphate‐buffered saline control or the free tubulysin analogue. Moreover, 37 % of the mice given the polymeric formulation were tumor free at the conclusion of the study.