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Synthesis and Bioactivity of Carbohydrate Derivatives of Indigo, Its Isomers and Heteroanalogues
Author(s) -
Karapetyan Gnuni,
Chakrabarty Kuheli,
Hein Martin,
Langer Peter
Publication year - 2011
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000374
Subject(s) - carbohydrate , indigo , chemistry , combinatorial chemistry , biochemistry , art , visual arts
Go indigo: Carbohydrate derivatives of indigoid bis‐indoles are effective inhibitors of several kinases, such as CDKs and GSK‐3β. Recent studies have shown that thia analogues of glycosylated indirubins are good candidates for the treatment of malignant melanoma. Herein we review the progress made in synthesis and biological screening of various carbohydrate derivatives of indigo, its isomers, and their heteroanalogues with special focus on synthetic issues.