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Inhibition of HIV‐1 Entry: Multiple Keys to Close the Door
Author(s) -
Hertje Maria,
Zhou Mingkui,
Dietrich Ursula
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000292
Subject(s) - human immunodeficiency virus (hiv) , intervention (counseling) , microbiology and biotechnology , chemistry , computational biology , biophysics , biology , virology , medicine , psychiatry
Locked out! HIV‐1 has evolved a complex multistep process to enter into cells that involves a series of time‐ordered conformational changes in its envelope proteins. Each of these entry intermediates offers the opportunity for therapeutic intervention.