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Ease of Synthesis, Controllable Sizes, and In Vivo Large‐Animal‐Lymph Migration of Polymeric Nanoparticles
Author(s) -
Zubris Kimberly Ann V.,
Khullar Onkar V.,
Griset Aaron P.,
GibbsStrauss Summer,
Frangioni John V.,
Colson Yolonda L.,
Grinstaff Mark W.
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000250
Subject(s) - nanoparticle , in vivo , lymph , polymerization , computer science , chemistry , nanotechnology , materials science , polymer , medicine , organic chemistry , pathology , biology , microbiology and biotechnology
Flying south for the winter! Polymeric nanoparticles were synthesized using either a photoinduced or base‐catalyzed free‐radical polymerization method. The particles (Ø=50 nm), loaded with a dye (IR‐786), were observed to migrate over 20 cm to the sentinel lymph node after injection in a live pig.