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A Novel Synthetic Route for the Anti‐HIV Drug MC‐1220 and its Analogues
Author(s) -
Loksha Yasser M.,
Globisch Daniel,
Loddo Roberta,
Collu Gabriella,
La Colla Paolo,
Pedersen Erik B.
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000244
Subject(s) - human immunodeficiency virus (hiv) , combinatorial chemistry , key (lock) , reagent , drug , computer science , reduction (mathematics) , drug discovery , chemistry , nanotechnology , materials science , mathematics , pharmacology , organic chemistry , virology , medicine , computer security , biochemistry , geometry
Easy street: Herein we describe a novel and practical synthesis of the anti‐HIV compound MC‐1220. Through the use of inexpensive reagents and commercially available starting materials, MC‐1220 and its analogues are more easily accessed by a four‐step procedure involving a key reduction step.