The DAT Ligand [ 18 F]PR17.MZ Mirrors the in vivo Pharmacokinetic Profile of [ 11 C]Cocaine with Significantly Improved Monoamine Transporter Selectivity | Zendy

Riss Patrick J. | Zendy; Piel Markus | Zendy; Bockhart Vanessa | Zendy; Bausbacher Nicole | Zendy; Buchholz HansGeorg | Zendy; Lueddens Hartmut | Zendy; Roesch Frank | Zendy

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The DAT Ligand [ 18 F]PR17.MZ Mirrors the in vivo Pharmacokinetic Profile of [ 11 C]Cocaine with Significantly Improved Monoamine Transporter Selectivity

Author(s) -

Riss Patrick J.,

Piel Markus,

Bockhart Vanessa,

Bausbacher Nicole,

Buchholz HansGeorg,

Lueddens Hartmut,

Roesch Frank

Publication year - 2010

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.201000237

Subject(s) - dopamine transporter , transporter , in vivo , ligand (biochemistry) , pharmacokinetics , selectivity , monoamine neurotransmitter , pharmacology , dopamine , chemistry , norepinephrine transporter , in vitro , psychology , medicine , neuroscience , biochemistry , receptor , gene , biology , genetics , serotonin , catalysis

Better than cocaine for your PET? The radiotracer [ 18 F]PR17.MZ shows high in vitro and in vivo selectivity to the dopamine transporter. Its extraordinarily rapid pharmacokinetic profile is demonstrated in a μPET imaging study. The relatively long half‐life of the fluorine‐18 label is an added advantage over short‐lived (−)‐ N ‐[ 11 C]cocaine PET ligands.

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