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Erythroid Induction of Chronic Myelogenous Leukemia K562 Cells Following Treatment with a Photoproduct Derived from the UV‐A Irradiation of 5‐Methoxypsoralen
Author(s) -
Salvador Alessia,
Dall'Acqua Stefano,
Sardo Manlio Sutera,
Caffieri Sergio,
Vedaldi Daniela,
Dall'Acqua Francesco,
Borgatti Monica,
Zuccato Cristina,
Bianchi Nicoletta,
Gambari Roberto
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000204
Subject(s) - k562 cells , chronic myelogenous leukemia , leukemia , in vitro , cell culture , cancer research , chemistry , cellular differentiation , precursor cell , biology , microbiology and biotechnology , immunology , biochemistry , genetics , gene
Induction of terminal erythroid differentiation can be an efficient strategy to inhibit proliferation of chronic myelogenous leukemia cells. Psoralens, well‐known photo‐chemotherapeutic agents, were found to be efficient at inducing erythroid differentiation of K562 cells, an in vitro cell line isolated from the pleural effusion of a patient with chronic myelogenous leukemia in blast crisis. The effects of crude pre‐irradiated solutions of 5‐methoxypsoralen on erythroid differentiation of human leukemic K‐562 cells were evaluated. The major photoproduct was characterized and analyzed, and it was found to induce erythroid differentiation of K562 cells and inhibit NF‐κB/DNA interactions.