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Synthesis of Fatty Acid Amides of Catechol Metabolites that Exhibit Antiobesity Properties
Author(s) -
Almeida Bruno,
Joglar Jesús,
Luque Rojas María Jesús,
Decara Juan Manuel,
BermúdezSilva Francisco Javier,
MaciasGonzález Manuel,
Fitó Montserrat,
RomeroCuevas Miguel,
Farré Magí,
Covas María Isabel,
Rodríguez de Fonseca Fernando,
de la Torre Rafael
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000161
Subject(s) - catechol , chemistry , fatty acid , biological activity , biochemistry , stereochemistry , in vitro
A series of fatty acid amides of 3,4‐methylenedioxymethamphetamine (MDMA) catechol metabolites were synthesized in order to evaluate their biological activities. Upon administration, all synthesized compounds resulted in negative modulation of food intake in rats. The most active compounds have affinity for the CB 1 receptor and/or PPAR‐ α ; part of their biological activity may be caused by these double interactions.