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Adenosine and 2′‐Deoxyadenosine Modified with Boron Cluster Pharmacophores as New Classes of Human Blood Platelet Function Modulators
Author(s) -
Bednarska Katarzyna,
Olejniczak Agnieszka B.,
Wojtczak Błażej A.,
Sułowska Zofia,
Leśnikowski Zbigniew J.
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000075
Subject(s) - deoxyadenosine , pharmacophore , platelet , adenosine , chemistry , pharmacology , biochemistry , human blood , platelet aggregation , computational biology , medicine , biology , immunology , physiology
Novel types of adenosine and 2′‐deoxyadenosine derivatives containing boron clusters at positions C2′, N6, or C8 were synthesized. The effect of these modified compounds on platelet function was studied. Modification of adenosine at the C2′ position with a para ‐carborane cluster (C 2 B 10 H 11 ) results in efficient inhibition of platelet function, including aggregation, protein secretion, and P‐selectin expression induced by thrombin or ADP. These preliminary findings and the new chemistry proposed form the basis for the development of a new class of adenosine analogues that modulate human blood platelet activities.