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Synthesis and Properties of a Photoactivatable Analogue of Psychosine (β‐Galactosylsphingosine)
Author(s) -
Lankalapalli Ravi S.,
Baksa Attila,
Liliom Károly,
Bittman Robert
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000018
Subject(s) - moiety , chemistry , photoaffinity labeling , benzophenone , stereochemistry , receptor , combinatorial chemistry , biochemistry , biophysics , organic chemistry , biology
Photoaffinity probes : The first synthesis of a photoaffinity probe of psychosine (blue) is reported, where benzophenone (red) is tethered as a crosslinking moiety. This photo‐psychosine probe (shown) displayed a similar potency as psychosine in stimulating Ca 2+ flux in U937 cells, suggesting that it may be useful for labeling and identifying the still unidentified psychosine receptor(s) by mass spectrometry.