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Structure of the Glucocorticoid Receptor, a Flexible Protein That Can Adapt to Different Ligands
Author(s) -
Veleiro Adriana S.,
Alvarez Lautaro D.,
Eduardo Silvina L.,
Burton Gerardo
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.201000014
Subject(s) - glucocorticoid receptor , ligand (biochemistry) , receptor , glucocorticoid , chemistry , function (biology) , small molecule , biophysics , microbiology and biotechnology , stereochemistry , computational biology , biology , biochemistry , endocrinology
Crystal structures of the glucocorticoid receptor (GR) ligand binding domain in complex with various agonists and antagonists give us an insight on how ligands are recognized by the receptor and how their structure can affect the behavior of the GR. Interestingly, these structural data show how the GR can adapt its binding pocket to accommodate molecules that differ substantially from the natural ligands without loss of function.