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Cover Picture: Evaluation of Novel Epothilone Analogues by means of a Common Pharmacophore and a QSAR Pseudoreceptor Model for Taxanes and Epothilones (ChemMedChem 1/2010)
Author(s) -
Forli Stefano,
Manetti Fabrizio,
Altmann KarlHeinz,
Botta Maurizio
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990062
Subject(s) - epothilones , pharmacophore , epothilone , paclitaxel , quantitative structure–activity relationship , chemistry , stereochemistry , cover (algebra) , tubulin , combinatorial chemistry , computational biology , biology , microtubule , cancer , engineering , genetics , mechanical engineering , microbiology and biotechnology
The cover picture shows paclitaxel bound to zinc‐induced tubulin sheets. Epothilone molecules and the common pharmacophoric hypothesis predicting the alignment between the two chemical classes in the β‐tubulin binding site are also shown. The image was generated using PMV 1.5.4. For more details, see the Communication by K.‐H. Altmann and M. Botta et al. on p. 35 ff.