Cover Picture: Interaction of Artemisinins with Oxyhemoglobin Hb–Fe II , Hb–Fe II , CarboxyHb–Fe II , Heme–Fe II , and Carboxyheme Fe II : Significance for Mode of Action and Implications for Therapy of Cerebral Malaria (ChemMedChem 12/2009) | Zendy

Coghi Paolo | Zendy; Basilico Nicoletta | Zendy; Taramelli Donatella | Zendy; Chan WingChi | Zendy; Haynes Richard K. | Zendy; Monti Diego | Zendy

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Cover Picture: Interaction of Artemisinins with Oxyhemoglobin Hb–Fe II , Hb–Fe II , CarboxyHb–Fe II , Heme–Fe II , and Carboxyheme Fe II : Significance for Mode of Action and Implications for Therapy of Cerebral Malaria (ChemMedChem 12/2009)

Author(s) -

Coghi Paolo,

Basilico Nicoletta,

Taramelli Donatella,

Chan WingChi,

Haynes Richard K.,

Monti Diego

Publication year - 2009

Publication title -

chemmedchem

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200990056

Subject(s) - chemistry , hemoglobin , carbon monoxide , heme , crystallography , biochemistry , enzyme , catalysis

The cover picture shows erythrocytes infected with malaria parasites after Giemsa staining (background). Heme, either within the hemoglobin (Hb) (ribbon diagram) or produced by catabolism of the Hb by the parasite, is considered to be responsible for the antimalarial activity of artemisinins (general structure shown). This hypothesis is examined more closely by use of carbon monoxide to passivate the Hb–iron complex. For more details, see the Full Paper by R. K. Haynes and D. Monti et al. on p. 2045 ff.

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