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Inside Cover: North‐ and South‐Bicyclo[3.1.0]Hexene Nucleosides: The Effect of Ring Planarity on Anti‐HIV Activity (ChemMedChem 8/2009)
Author(s) -
Russ Pamela L.,
GonzalezMoa Maria J.,
Vu B. Christie,
Sigano Dina M.,
Kelley James A.,
Lai Christopher C.,
Deschamps Jeffrey R.,
Hughes Stephen H.,
Marquez Victor E.
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990036
Subject(s) - chemistry , planarity testing , cyclopentene , stereochemistry , ring (chemistry) , bicyclic molecule , human immunodeficiency virus (hiv) , cover (algebra) , crystallography , organic chemistry , biology , virology , mechanical engineering , engineering , catalysis
The inside cover picture shows the locked north (blue) and south (red) bicyclo[3.1.0]hexane nucleosides in the normal pseudorotational cycle, and the corresponding shift to a smaller cycle ( n max =7 °) caused by the insertion of a double bond. The former nucleosides are inactive, while the flattening of the embedded cyclopentene ring provides active compounds against HOS cells infected with HIV. For more details, see the Full Paper by V. E. Marquez et al. on p. 1354 ff.