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Inside Cover: Development of Novel Thiazolopyrimidines as CDC25B Phosphatase Inhibitors (ChemMedChem 4/2009)
Author(s) -
Kolb Stéphanie,
Mondésert Odile,
Goddard MaryLorène,
Jullien Denis,
Villoutreix Bruno O.,
Ducommun Bernard,
Garbay Christiane,
Braud Emmanuelle
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990016
Subject(s) - docking (animal) , active site , cover (algebra) , chemistry , moiety , ribbon , stereochemistry , cdc25 , combinatorial chemistry , catalysis , geometry , biochemistry , engineering , mathematics , mechanical engineering , medicine , cyclin dependent kinase 1 , nursing , cell cycle , cell
The inside cover picture shows a possible docking pose of a thiazolopyrimidine ligand (stick representation) in the active site of CDC25 shown as a ribbon diagram. The dioxolane moiety is located in the catalytic site loop whereas the dibromohydroxyphenyl part is pointing toward the adjacent “swimming pool”. For more details, see the Full Paper by E. Braud et al. on p. 633 ff.