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Cover Picture: Inhibition of Peroxidase‐Catalyzed Iodination by Cephalosporins: Metallo‐β‐Lactamase‐Induced Antithyroid Activity of Antibiotics (ChemMedChem 4/2009)
Author(s) -
Tamilselvi A.,
Mugesh Govindasamy
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990015
Subject(s) - chemistry , antibiotics , cephalosporin , peroxidase , hydrolysis , catalysis , enzyme , halogenation , thyroid peroxidase , tyrosine , cover (algebra) , combinatorial chemistry , biochemistry , organic chemistry , mechanical engineering , engineering , hormone
The cover picture shows some commonly used antibiotics with heterocyclic side chains inhibit peroxidase‐catalyzed iodination of L‐tyrosine upon hydrolysis by the bacterial enzyme metallo‐beta‐lactamase. This suggests that the production of metallo‐beta‐lactamase and subsequent hydrolysis of antibiotics would affect thyroid activity. For more details, see the Communication by A. Tamilselvi and G. Mugesh on p. 512 ff.