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Inside Cover: Cytotoxicities and Structure–Activity Relationships of Natural and Unnatural Lamellarins toward Cancer Cell Lines (ChemMedChem 3/2009)
Author(s) -
Chittchang Montakarn,
Batsomboon Paratchata,
Ruchirawat Somsak,
Ploypradith Poonsakdi
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990011
Subject(s) - cytotoxicity , chemistry , cancer cell lines , topoisomerase , stereochemistry , cover (algebra) , cytotoxic t cell , dna , cancer cell , cancer , biology , biochemistry , genetics , in vitro , mechanical engineering , engineering
The inside cover picture shows the structure of lamellarin N as a representative of cytotoxic marine lamellarin alkaloids, together with a potential molecular target, the topoisomerase I–DNA complex. Systematic SAR studies revealed the importance of the substituents for potent cytotoxicity. For more details, see the Full Paper by P. Ploypradith et al. on p. 457 ff.