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Cover Picture: Exploring the Implications of Vitamin B 12 Conjugation to Insulin on Insulin Receptor Binding (ChemMedChem 3/2009)
Author(s) -
Petrus Amanda K.,
Allis Damian G.,
Smith Robert P.,
Fairchild Timothy J.,
Doyle Robert P.
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990010
Subject(s) - conjugate , insulin , chemistry , deliverable , insulin receptor , cover (algebra) , endocrinology , stereochemistry , medicine , insulin resistance , mathematics , mechanical engineering , mathematical analysis , management , engineering , economics
The cover picture shows three views of a vitamin B 12 –insulin conjugate bound to transcobalamin II, docked in the insulin receptor (IR). This study reveals how the structure of an orally deliverable insulin changes in solution after vitamin B 12 conjugation and its effect on IR binding capacity. The results demonstrate that chemical modification of insulin by linking relatively large pendant groups does not interfere with IR recognition. For more details, see the Full Paper by T. J. Fairchild, R. P. Doyle, et al. on p. 421 ff.