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Cover Picture: Structure–Activity Relationship Analysis of the Peptide Deformylase Inhibitor 5‐Bromo‐1 H ‐indole‐3‐acetohydroxamic Acid (ChemMedChem 2/2009)
Author(s) -
Petit Sylvain,
Duroc Yann,
Larue Valéry,
Giglione Carmela,
Léon Carole,
Soulama Coralie,
Denis Alexis,
Dardel Frédéric,
Meinnel Thierry,
Artaud Isabelle
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990004
Subject(s) - bacillus subtilis , acetohydroxamic acid , indole test , staphylococcus aureus , streptococcus pneumoniae , chemistry , antibacterial activity , antibacterial peptide , microbiology and biotechnology , stereochemistry , derivative (finance) , peptide , cover (algebra) , biochemistry , bacteria , urease , biology , enzyme , antibiotics , genetics , financial economics , economics , mechanical engineering , engineering
The cover picture shows a “reverse” indole derivative in complex with Bacillus stearothermophilus peptide deformylase (PDF). This compound was selected from a structure–activity relationship study as a potent inhibitor of bacterial PDFs and shows antibacterial activity toward Bacillus subtilis as well as other pathogens such as Streptococcus pneumoniae and Staphylococcus aureus. For more details, see the Full Paper by I. Artaud et al. on p. 261 ff.