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Cover Picture: Diphenyl Ether Non‐Nucleoside Reverse Transcriptase Inhibitors with Excellent Potency Against Resistant Mutant Viruses and Promising Pharmacokinetic Properties (ChemMedChem 1/2009)
Author(s) -
Sweeney Zachary K.,
KennedySmith Joshua J.,
Wu Jeffrey,
Arora Nidhi,
Billedeau J. Roland,
Davidson James P.,
Fretland Jennifer,
Hang Julie Q.,
Heilek Gabrielle M.,
Harris Seth F.,
Hirschfeld Donald,
Inbar Petra,
Javanbakht Hassan,
Jernelius Jesper A.,
Jin Qingwu,
Li Yu,
Liang Weiling,
Roetz Ralf,
Sarma Keshab,
Smith Mark,
Stefanidis Dimitrio,
Su Guoping,
Suh Judy M.,
Villaseñor Armando G.,
Welch Michael,
Zhang FangJie,
Klumpp Klaus
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200990000
Subject(s) - reverse transcriptase , chemistry , protein data bank (rcsb pdb) , stereochemistry , primer (cosmetics) , mutant , nucleotide , nucleoside , dna polymerase , dna , nucleoside reverse transcriptase inhibitor , microbiology and biotechnology , biochemistry , biology , rna , gene , organic chemistry
The cover picture shows a cut‐away view of a diaryl ether non‐nucleoside reverse transcriptase inhibitor (cyan) bound to HIV reverse transcriptase. The cartoon representation of the DNA template (teal) and primer (gold) strands, as well as the incoming nucleotide molecule, are shown as landmarks and aligned from a separate structure (PDB code 1RTD). Binding of the non‐nucleoside inhibitor interferes with the precise alignment and dynamics of the growing strand and the polymerase catalytic center. For more details, see the Full Paper by Z. K. Sweeney et al. on p. 88 ff.