Aminocarnitine Ureidic Derivatives as Inhibitors of Carnitine Palmitoyltransferase I | Zendy

Tassoni Emanuela | Zendy; Conti Roberto | Zendy; Gallo Grazia | Zendy; Vincenti Silvia | Zendy; Dell'Uomo Natalina | Zendy; Mastrofrancesco Lucilla | Zendy; Ricciolini Rita | Zendy; Cabri Walter | Zendy; Carminati Paolo | Zendy; Giannessi Fabio | Zendy

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Aminocarnitine Ureidic Derivatives as Inhibitors of Carnitine Palmitoyltransferase I

Author(s) -

Tassoni Emanuela,

Conti Roberto,

Gallo Grazia,

Vincenti Silvia,

Dell'Uomo Natalina,

Mastrofrancesco Lucilla,

Ricciolini Rita,

Cabri Walter,

Carminati Paolo,

Giannessi Fabio

Publication year - 2010

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200900535

Subject(s) - chemistry , carnitine o palmitoyltransferase , carnitine , pharmacology , stereochemistry , biochemistry , combinatorial chemistry , enzyme , medicine , beta oxidation

Aminocarnitine ureidic derivatives were synthesized and evaluated as liver‐isoform‐selective carnitine palmitoyltransferase (CPT) I inhibitors. The most interesting molecule identified ( 3 ), the corresponding phosphonium analogue ( 4 ) showed improved efficacy in vitro and in vivo over the previously identified compound 1 (teglicar, ST1326).

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