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Discovery of Phthalimides as Immunomodulatory and Antitumor Drug Prototypes
Author(s) -
Pessoa Claudia,
Ferreira Paulo Michel P.,
Lotufo Letícia Veras C.,
de Moraes Manoel O.,
Cavalcanti Suellen M. T.,
Coêlho Lucas Cunha D.,
Hernandes Marcelo Z.,
Leite Ana Cristina L.,
De Simone Carlos A.,
Costa Vlaudia M. A.,
Souza Valdênia M. O.
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900525
Subject(s) - phthalimides , nitric oxide , drug , drug discovery , potency , pharmacology , thalidomide , computational biology , computer science , combinatorial chemistry , chemistry , medicine , biology , in vitro , biochemistry , immunology , organic chemistry , phthalimide , multiple myeloma
Optimized anticancer agents : A set of functionalized phthalimides was synthesized and evaluated for antitumor activities and as modulators of the secretion of cytokines and nitric oxide. Their potency was compared with that of thalidomide, and as a result, a new potent anticancer and immunomodulatory agent, compound 2 b , was identified.