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Oxa‐azaspiro Derivatives: a Novel Class of Triple Re‐uptake Inhibitors
Author(s) -
Bettati Michela,
Cavanni Paolo,
Di Fabio Romano,
Oliosi Beatrice,
Perini Ornella,
Scheid Gunther,
Tedesco Giovanna,
Zonzini Laura,
Micheli Fabrizio
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900482
Subject(s) - pharmacophore , in silico , binding affinities , chemistry , in vivo , affinities , in vitro , stereochemistry , combinatorial chemistry , computational biology , biochemistry , biology , gene , receptor , genetics
Oxa‐aza spiro compounds : In silico techniques were successfully employed to predict the rank order of derivatives based on their binding affinities to the monoamine transporters, SERT, NET and DAT. The proposed scaffolds derived from the pharmacophore model were experimentally evaluated in vitro and in vivo. A new class of selective “triple” re‐uptake inhibitors was discovered, that may be developed further to give novel antidepressant agents.