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Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
Author(s) -
Gattii Sonia,
De Simone Chiara,
Dallavalle Sabrina,
Fezza Filomena,
Nannei Raffaella,
Amadio Daniele,
Minetti Patrizia,
Quattrociocchi Gianandrea,
Caprioli Antonio,
Borsini Franco,
Cabri Walter,
Penco Sergio,
Merlini Lucio,
Maccarrone Mauro
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900472
Subject(s) - fatty acid amide hydrolase , endocannabinoid system , enol , chemistry , selectivity , amidase , amide , fatty acid , biochemistry , enzyme , stereochemistry , cannabinoid receptor , catalysis , receptor , agonist
FAAH inhibitors : This study identifies a new class of enol carbamates as potent, reversible inhibitors of fatty acid amide hydrolase (FAAH), endowed with high selectivity towards this target over other components of the endocannabinoid system.