Premium
Water‐soluble Organometallic Analogues of Oxaliplatin with Cytotoxic and Anticlonogenic Activity
Author(s) -
Benedetti Michele,
Antonucci Daniela,
Migoni Danilo,
Vecchio Vita M.,
Ducani Cosimo,
Fanizzi Francesco P.
Publication year - 2010
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900412
Subject(s) - oxaliplatin , prodrug , cationic polymerization , chemistry , group 2 organometallic chemistry , stereochemistry , combinatorial chemistry , computer science , biochemistry , organic chemistry , medicine , cancer , molecule , colorectal cancer
Pt prodrugs : We synthesized new cationic complexes [PtCl(η 2 ‐C 2 H 4 )( R , R ‐chxn)]Cl ( 1 ) and [PtCl(η 2 ‐C 2 H 4 )( S , S ‐chxn)]Cl ( 2 ), which are organometallic analogues of the drug oxaliplatin. Complexes 1 and 2 can be considered antitumor prodrugs, as we demonstrate that they can decompose to give the same metabolites as those of oxaliplatin.