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Chemical and Structural Biology to Direct the Repurposing of Sulindac
Author(s) -
Simard Jeffrey R.,
Rauh Daniel
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900384
Subject(s) - sulindac , chemical biology , repurposing , nonsteroidal , cyclooxygenase , inflammation , wnt signaling pathway , drug repositioning , drug discovery , pharmacology , chemistry , enzyme , drug , biology , signal transduction , biochemistry , immunology , ecology
Chemical biology for medicinal chemistry : The nonsteroidal anti‐inflammatory drug sulindac was originally developed to inhibit cyclooxygenase enzymes (COX1/2) to treat inflammation and pain. Recent studies have shown that sulindac also acts on the Wnt signaling pathway, a target relevant to cancer.
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