The Roles of 3′ and 4′ Hydroxy Groups in α‐Galactosylceramide Stimulation of Invariant Natural Killer T Cells | Zendy

Xia Chengfeng | Zendy; Zhang Wenpeng | Zendy; Zhang Yalong | Zendy; Chen Wenlan | Zendy; Nadas Janos | Zendy; Severin Ryan | Zendy; Woodward Robert | Zendy; Wang Bin | Zendy; Wang Xin | Zendy; Kronenberg Mitchell | Zendy; Wang Peng G. | Zendy

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The Roles of 3′ and 4′ Hydroxy Groups in α‐Galactosylceramide Stimulation of Invariant Natural Killer T Cells

Author(s) -

Xia Chengfeng,

Zhang Wenpeng,

Zhang Yalong,

Chen Wenlan,

Nadas Janos,

Severin Ryan,

Woodward Robert,

Wang Bin,

Wang Xin,

Kronenberg Mitchell,

Wang Peng G.

Publication year - 2009

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200900350

Subject(s) - stimulation , invariant (physics) , chemistry , immunology , microbiology and biotechnology , stereochemistry , biology , neuroscience , mathematics , mathematical physics

NKT cell stimulation : C3′‐ and C4′‐modified α‐galactosylceramide (α‐GalCer) analogues show that the 3′‐OH group is crucial for maintaining α‐GalCer immunogenicity; any modifications at this position lead to loss of activity. However, the C4′ position is less sensitive and tolerates minor modifications. Moreover, C4′‐substituted analogues can induce the release of biased T h 2 cytokines.

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