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The Roles of 3′ and 4′ Hydroxy Groups in α‐Galactosylceramide Stimulation of Invariant Natural Killer T Cells
Author(s) -
Xia Chengfeng,
Zhang Wenpeng,
Zhang Yalong,
Chen Wenlan,
Nadas Janos,
Severin Ryan,
Woodward Robert,
Wang Bin,
Wang Xin,
Kronenberg Mitchell,
Wang Peng G.
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900350
Subject(s) - stimulation , invariant (physics) , chemistry , immunology , microbiology and biotechnology , stereochemistry , biology , neuroscience , mathematics , mathematical physics
NKT cell stimulation : C3′‐ and C4′‐modified α‐galactosylceramide (α‐GalCer) analogues show that the 3′‐OH group is crucial for maintaining α‐GalCer immunogenicity; any modifications at this position lead to loss of activity. However, the C4′ position is less sensitive and tolerates minor modifications. Moreover, C4′‐substituted analogues can induce the release of biased T h 2 cytokines.