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High‐Speed Microwave‐Assisted Synthesis of the Trifluoromethylpyrazol‐Derived Canonical Transient Receptor Potential (TRPC) Channel Inhibitor Pyr3
Author(s) -
Glasnov Toma N.,
Groschner Klaus,
Kappe C. Oliver
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900304
Subject(s) - trpc5 , trpc , nfat , transient receptor potential channel , microwave , computer science , trpc3 , chemistry , computational biology , transcription factor , telecommunications , biochemistry , biology , receptor , gene
Process intensification using controlled microwave heating allows an efficient three‐step synthesis of pyrazole‐based inhibitors of TRPC3 and related NFAT transcription factor regulators. Compared to the conventional protocol, a dramatic reduction in overall processing time from ∼2 days to 40 min was achieved, accompanied by significantly improved product yields.