High‐Speed Microwave‐Assisted Synthesis of the Trifluoromethylpyrazol‐Derived Canonical Transient Receptor Potential (TRPC) Channel Inhibitor Pyr3 | Zendy

Glasnov Toma N. | Zendy; Groschner Klaus | Zendy; Kappe C. Oliver | Zendy

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High‐Speed Microwave‐Assisted Synthesis of the Trifluoromethylpyrazol‐Derived Canonical Transient Receptor Potential (TRPC) Channel Inhibitor Pyr3

Author(s) -

Glasnov Toma N.,

Groschner Klaus,

Kappe C. Oliver

Publication year - 2009

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200900304

Subject(s) - trpc5 , trpc , nfat , transient receptor potential channel , microwave , computer science , trpc3 , chemistry , computational biology , transcription factor , telecommunications , biochemistry , biology , receptor , gene

Process intensification using controlled microwave heating allows an efficient three‐step synthesis of pyrazole‐based inhibitors of TRPC3 and related NFAT transcription factor regulators. Compared to the conventional protocol, a dramatic reduction in overall processing time from ∼2 days to 40 min was achieved, accompanied by significantly improved product yields.

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