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Aminocyclitol‐Substituted Phytoceramides and their Effects on iNKT Cell Stimulation
Author(s) -
Harrak Youssef,
Barra Carolina M.,
Bedia Carmen,
Delgado Antonio,
Castaño A. Raúl,
Llebaria Amadeu
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900193
Subject(s) - aminocyclitol , stimulation , chemistry , biology , neuroscience , biochemistry , aminoglycoside , antibiotics
Natural born killers : Nonglycosidic α‐galactosylceramide (α‐GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α‐GalCer but with lower potency, and induces the release of IFNγ and IL‐4 in iNKT cell culture causing a biased Th2 cytokine profile response.