Aminocyclitol‐Substituted Phytoceramides and their Effects on iNKT Cell Stimulation | Zendy

Harrak Youssef | Zendy; Barra Carolina M. | Zendy; Bedia Carmen | Zendy; Delgado Antonio | Zendy; Castaño A. Raúl | Zendy; Llebaria Amadeu | Zendy

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Aminocyclitol‐Substituted Phytoceramides and their Effects on iNKT Cell Stimulation

Author(s) -

Harrak Youssef,

Barra Carolina M.,

Bedia Carmen,

Delgado Antonio,

Castaño A. Raúl,

Llebaria Amadeu

Publication year - 2009

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200900193

Subject(s) - aminocyclitol , stimulation , chemistry , biology , neuroscience , biochemistry , aminoglycoside , antibiotics

Natural born killers : Nonglycosidic α‐galactosylceramide (α‐GalCer) analogues, with a polyhydroxylated aminocyclohexane moiety as the galactose surrogate, constitute a new class of charged NKT cell agonists. One of these compounds, HS44, promotes in vitro NKT cell expansion in a similar fashion to α‐GalCer but with lower potency, and induces the release of IFNγ and IL‐4 in iNKT cell culture causing a biased Th2 cytokine profile response.

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