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Synthesis, Crystal Structure and Immunosuppressive Activity of Acylamide Derivatives Containing 1,4‐Benzodioxan
Author(s) -
Lv PengCheng,
Wang KaiRui,
Mao WenJun,
Xiong Jing,
Li HuanQiu,
Yang Ying,
Shi Lei,
Zhu HaiLiang
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900167
Subject(s) - concanavalin a , chemistry , ic50 , computational biology , computer science , stereochemistry , combinatorial chemistry , biology , biochemistry , in vitro
Immunosuppressive agents : Twenty‐four acylamide derivatives, all with a 1,4‐benzodioxan template, were synthesized and screened for immunosuppressive activity. Compound 4 c (shown) exhibited significant inhibition of concanavalin A (ConA) induced T cell proliferation (IC 50 =0.42 μmol L −1 ) comparable to that of the reference compound cyclosporin A, and represents a promising lead for the development of novel therapeutic agents.