Synthesis, Crystal Structure and Immunosuppressive Activity of Acylamide Derivatives Containing 1,4‐Benzodioxan | Zendy

Lv PengCheng | Zendy; Wang KaiRui | Zendy; Mao WenJun | Zendy; Xiong Jing | Zendy; Li HuanQiu | Zendy; Yang Ying | Zendy; Shi Lei | Zendy; Zhu HaiLiang | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Synthesis, Crystal Structure and Immunosuppressive Activity of Acylamide Derivatives Containing 1,4‐Benzodioxan

Author(s) -

Lv PengCheng,

Wang KaiRui,

Mao WenJun,

Xiong Jing,

Li HuanQiu,

Yang Ying,

Shi Lei,

Zhu HaiLiang

Publication year - 2009

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200900167

Subject(s) - concanavalin a , chemistry , ic50 , computational biology , computer science , stereochemistry , combinatorial chemistry , biology , biochemistry , in vitro

Immunosuppressive agents : Twenty‐four acylamide derivatives, all with a 1,4‐benzodioxan template, were synthesized and screened for immunosuppressive activity. Compound 4 c (shown) exhibited significant inhibition of concanavalin A (ConA) induced T cell proliferation (IC 50 =0.42 μmol L −1 ) comparable to that of the reference compound cyclosporin A, and represents a promising lead for the development of novel therapeutic agents.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research