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Discovery of a New Class of Non‐imidazole Oxazoline‐Based Histamine H 3 Receptor (H 3 R) Inverse Agonists
Author(s) -
Célanire Sylvain,
Wijtmans Maikel,
Christophe Bernard,
Collart Philippe,
de Esch Iwan,
Dassesse Donald,
Delaunoy Christel,
Dene Frédéric,
Durieu Véronique,
Gelens Edith,
Gillard Michel,
Lallemand Bénédicte,
Lamberty Yves,
Lebon Florence,
Nicolas JeanMarie,
Quéré Luc,
Snip Erwin,
Vanbellinghen Alain,
Van houtvin Nathalie,
Verbois Valérie,
Timmerman Henk,
Talaga Patrice,
Leurs Rob,
Provins Laurent
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900055
Subject(s) - imidazole , class (philosophy) , histamine , oxazoline , chemistry , histamine receptor , inverse , stereochemistry , receptor , mathematics , biochemistry , biology , computer science , catalysis , pharmacology , artificial intelligence , antagonist , geometry
H 3 R inverse agonists based on an aminopropoxy‐phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.