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Design and Synthesis of Trypanosoma brucei Active 1‐Alkyloxy and 1‐Benzyloxyadamantano 2‐Guanylhydrazones
Author(s) -
Papanastasiou Ioannis,
Tsotinis Andrew,
Zoidis Grigoris,
Kolocouris Nicolas,
Prathalingam S. Radhika,
Kelly John M.
Publication year - 2009
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200900019
Subject(s) - trypanosoma brucei , stereochemistry , african trypanosomiasis , biology , chemistry , computational biology , trypanosomiasis , combinatorial chemistry , biochemistry , virology , gene
Treating African trypanosomiasis : The synthesis and biological evaluation of novel 1‐alkyloxy and 1‐benzyloxyadamantano 2‐guanylhydrazones, their 1‐dioxa congeners and two 1‐benzyladamantano 2‐guanylhydrazones is reported. Preliminary structure–activity relationship data were elucidated and lead compounds suitable for further optimization were discovered.